This Information Applies To: Agilent ELSDs G4260A, G4260B, G4261A, G4621B, G7102A, G7102B
If the evaporator tube of ELSD becomes contaminated with non-volatile material resulting in poor chromatography, please use the steps below to troubleshoot and clean the ELSD.
Steps to Follow:
It is recommended that the instrument is initially washed with a solvent suitable to clean the contamination.
Caution: Do not use solvents that contain additives when performing the cleaning procedure.
Caution: Please read all relevant MSDS for the solvents being used, and follow all safety guidance including storage, handling, ventilation and extraction requirements, and the use of appropriate PPE.
One of the “cleaning” solvents recommended is Acetone/Water (50/50) (based on your application, select the appropriate solvent to clean the contamination).
Depending on use, it is recommended to clean the evaporator tube at least once a week or every 40 hours.
The build-up of contamination can be identified early by monitoring the baseline noise over time, or by checking the ELSD offset reading.
To check the ELSD offset value;
It is also recommended to clean the unit following the use of buffers, or where the sample matrix contains impurities (i.e. "dirty" sample).
If cleaning the unit does not cure the problems then contact Agilent Technologies for further assistance.
Learn how to effectively maintain your Agilent ELSD:
ELSD User Manual on Agilent.com