In MassHunter Quantitative Analysis software, there is a script that allows specific compounds to be used for semi quantitative analysis. Proper implementation of this script requires that specific compounds groups be established referencing the individual compounds whose response factors will be used to “semi-quantitate” unknown compounds. This utility differs from the Relative ISTD global parameter and the Copy Calibration Levels To command in the sense that it is based on the compound group (Cmpd.Group) concept referencing the target or internal standards (ISTD). See the attached document for detailed instructions on how to set up and use this script.