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Dissolution Tips and Tricks from Application Engineers
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  • Dissolution Day in Waldbronn: 400-DS in Focus

    Dissolution Day in Waldbronn: 400-DS in Focus

    dan.spisak
    dan.spisak
    By: karen.krauel-goellner  It was with great pleasure and excitement to host the first Agilent 400-DS workshop at our customer center in Waldbronn, Germany on January 17, 2023. This hybrid event included attendees and presenters joining us ...
    • 30 Jan 2023
  • What is the NanoDis Advantage? See 3 New Application Notes for Details!

    What is the NanoDis Advantage? See 3 New Application Notes for Details!

    dan.spisak
    dan.spisak
    The Agilent NanoDis system combines traditional USP Apparatus 1 and 2 instrumentation with automation and compliance in an ideal system for scientists looking to optimize formulation development. While initially designed for the dissolution...
    • 17 Jan 2023
  • Dissolution Discussion Group (DDG) Event Calendar for 2023 - Register Now!

    Dissolution Discussion Group (DDG) Event Calendar for 2023 - Register Now!

    dan.spisak
    dan.spisak
    The Dissolution Discussion Group (DDG) is an independent forum which gives you the opportunity to ask questions and discuss key topics that affect the day-to-day task of developing, performing, and validating dissolution methods and their relat...
    • 28 Dec 2022
  • What You Need to Know About Deaeration of Dissolution Media

    What You Need to Know About Deaeration of Dissolution Media

    dan.spisak
    dan.spisak
    Deaeration, or degassing, is the controlled process of removing excess dissolved gases, primarily air, from dissolution media. When performing dissolution testing, this can be one of the biggest headaches in the lab; and, if not done properly, is one...
    • 14 Oct 2022
  • Choosing the Right Filter for Your Dissolution Method

    Choosing the Right Filter for Your Dissolution Method

    dan.spisak
    dan.spisak
    Filter selection is one of the most critical and misunderstood aspects of Dissolution. This post includes key points regarding this topic as well as important links to further information from Agilent and Cytiva filtration experts.
    • 30 Aug 2022
  • Research Advice for Dissolution Method Development

    Research Advice for Dissolution Method Development

    dan.spisak
    dan.spisak
    Working with a new formulation typically requires development of a new dissolution method. What apparatus or media should you use? If the product is already well established, do you need to start from scratch? In this post, Ken Boda delivers key advice as well as a collection of resources available to help get you moving in the right direction.
    • 25 Jul 2022
  • Exploring Small Volume Dissolution for Low-Dose Products or Medical Devices

    Exploring Small Volume Dissolution for Low-Dose Products or Medical Devices

    dan.spisak
    dan.spisak
    Low-dose formulations and medical devices are becoming more common. For these products, typical dissolution volumes of 500 - 900 mL are too high to get appropriate analysis on UV-Vis or HPLC and smaller volumes are needed. In this post, Agilent&rsquo...
    • 30 Jun 2022
  • Are You Having Dissolution Method Development Challenges? Have You Considered USP Apparatus 3?

    Are You Having Dissolution Method Development Challenges? Have You Considered USP Apparatus 3?

    dan.spisak
    dan.spisak
    (The following article is paraphrased from a previous LinkedIn post by kenboda, Agilent’s US Product Specialist for Dissolution.) The vast majority of dissolutions are performed using USP Apparatus 1 (baskets) and 2 (paddles), but when sho...
    • 14 Jun 2022
  • Overcoming Coning Issues with Apex (Peak) Vessels

    Overcoming Coning Issues with Apex (Peak) Vessels

    dan.spisak
    dan.spisak
    The Apex (Peak) vessel continues to gain momentum in the dissolution testing arena. A recently published Stimuli article from industry experts (link at bottom of article) reflects this position with supporting data from several case studies. Hear Agi...
    • 31 May 2022
  • What Is Sink Condition in Dissolution Testing?

    What Is Sink Condition in Dissolution Testing?

    dan.spisak
    dan.spisak
    Sink condition is mentioned a lot when it comes to dissolution testing, but its importance is often left out. The background and relevance of this topic is further described and discussed by kenboda , Dissolution Product Specialist at Agilent. T...
    • 16 May 2022
  • What is USP's Q Value for Dissolution Testing?

    dan.spisak
    dan.spisak
    (originally posted by Ken Boda, Dissolution Product Specialist on LinkedIn) One question I frequently get is about Q in the USP. What is Q? How to I determine Q? How do I interpret the acceptance tables? USP defines Q as the quantity or the "amount o...
    • 5 May 2022
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