This Information Applies To: Agilent OpenLab CDS, G7110B Isocratic Pump, G7111A/B, G5654A Quaternary Pumps, and G7112B Binary Pump.
Incorrectly applied solvent compressibilities can result in an increased pressure ripple, or inaccurate solvent composition in LC pumps.
In HPLC, liquids under high pressures are pumped through the system, which can result in measurable liquid compression. Though the amount of compression is very small, it is enough to change the flow rate of the system. Incorrect compressibility compensation will affect the resulting volume of solvent that is moved to the system, leading to pressure ripples, and inaccurate solvent compositions.
Steps to Follow
Tips: For binary pumps, you can adjust the value for each individual pump head. Isocratic and quaternary pumps will only have one value that can be adjusted.
Learn how to effectively operate your Agilent Infinity LC:
HPLC-OLII-1121e - Agilent Infinity LC Systems with OpenLab CDS – Acquisition Method e-learning course available from Agilent education