Same sample injections with huge difference in response, what could cause this?


we currently are using1290 Infinity II LC and we are having a problem with injections with in the same sample but the response being significantly different between the two. We have changed the needle, cleaned the source and checktune the instrument and are currently recalibrating to see if that fixed the problem. If not do you have any other suggestions on what we can do, we just do not trust the results. Thanks for you help.

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