No signal Agilent 6470A

Hello, could you advise me? JetStream ESI Agilent 6470a coupled with Agilent 1260 Infiniti.

The signal is completely gone. It doesn't matter where the liquid comes from in mass-spec - from HPLC, through the tuning line or directly from the syringe - the effect is the same - zero signal. Tuning mixture, chloramphenicol, reserpine, polytyrosine - nothing is detected.

At the same time, the nebulizer forms a good spray. What could be the problem?

P.S. It is interesting that the capillary current does not change much and, regardless of the presence or absence of a spray, it remains about 2000 nA. Could this be an isolator problem?


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