High Consumption of Reference Mass Solution

Hi everyone,

I have a question about the reference mass solution, which we use with our QToF 6540B (with Dual AJS ESI). The consumption of the solution is relatively high in my opinion. A 100 mL bottle is barely enough for an analysis over night (~14 h). I wanted to ask, if this high demand is normal, or if our device is maybe somehow set up false.

Thank you very much for your inputs.

All the best

Jan

Parents
  • Hi Jan, 

    I have a 45XT and ours last many days worth of continuous feed. If I recall, it's supposed to only consume ~10-20 uL/min so it should last quite a while. Yours is more like 100uL/hr. Typically if there's a leak, it will set off the sensor but you should check under the cover just in case.  

    Your CDS could be plumbed incorrectly but I think it's really just a solenoid and a very long PEEK line. If the line hasn't been trimmedback, there's not many places for it to go. 

    Do you see a ripple in the surface of the reference mass solution when the bottle is installed? It could mean you're not getting a good seal and you're evaporation it via N2. The glass bottles are notoriously hit or miss in terms of the seal.  

Reply
  • Hi Jan, 

    I have a 45XT and ours last many days worth of continuous feed. If I recall, it's supposed to only consume ~10-20 uL/min so it should last quite a while. Yours is more like 100uL/hr. Typically if there's a leak, it will set off the sensor but you should check under the cover just in case.  

    Your CDS could be plumbed incorrectly but I think it's really just a solenoid and a very long PEEK line. If the line hasn't been trimmedback, there's not many places for it to go. 

    Do you see a ripple in the surface of the reference mass solution when the bottle is installed? It could mean you're not getting a good seal and you're evaporation it via N2. The glass bottles are notoriously hit or miss in terms of the seal.  

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