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I am using an InfinityLab Poroshell 120 HILIC-Z. For pH adjustment, 0.2N HCl. Source conditions (if I understand what you mean) are ESI with a flow rate of 0.5mL/min.
Hi Katy,
Looks like you are coating the spray chamber with ammonium chloride, not ammonium format. I wouldn't recommend using HCl to reduce the pH of your ammonium formate. Adjust the pH with formic acid instead, and he problem should go away.
Kind regards
Andy
I think Andy's right (pun intended). I've seen this a couple times before where insoluble salts were formed when adjusting pH.
I would probably recommend having your system cleaned/PM'd if you are able to. Last time this happened, it made it all the way back to the quads.