There is a strong interference ion signal, M/Z=102, and it is suspected to be the pollution of triethylamine. How can we clean it best and effectively?
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There is a strong interference ion signal, M/Z=102, and it is suspected to be the pollution of triethylamine. How can we clean it best and effectively?
Hi dong0002,
Were you doing negative ion before? TEA is a very difficult contamination to remove.
You can also try the following:
1. Rinse the source with isopropanol, water, 25% nitric acid (15'), water (1,5 h),(remove from MS)
2. Clean the whole ion path , depends on MS
You will also need to clean the whole LC.
3. Exchanging all peek-capillaries
4. ultrasonic of the rotor seals in isopropanol
5. Rinse the whole hplc with 25% nitric acid for 15 Minutes
6. Rinse the whole system with water, purge the pulse damper several times
7. Rinse the system one night with 50% isopropanol/water with 0.1% FA
Thank you for your answer
Thank you for your answer