Reduced sensitivity with MeOH as a solvent

I am running terpenes on an HP-6890 with an autosampler and an FID, injecting 1 ul using 10:1 split with hydrogen as a carrier gas.  I observed that when my standards are dissolved in MeOH the response of all peaks is about 1/4 of that in Heptane.  What could be the reason for that?

Parents Reply Children
  • Hear hear.  I also now have experience using acetonitrile and the peak shape is bad (fronting) - I have seen this peak shape when I accidently have the split set up to 0.6:1 in methanol.  And I also decided to solvent-match my standards and samples.  I still would like to understand my observation of MeOH vs Heptane.

Was this helpful?