Issue with MRM to dMRM Switch.

Question

I'm currently encountering a challenging issue with MassHunter Acquisition Software that has significantly hindered my workflow. I am hoping to leverage the community's expertise to find an effective resolution. 
 Switching from MRM to dMRM Settings Error: 
 
 Issue: Every attempt to switch from MRM to dMRM in the software triggers an error, disrupting my analysis setup. 
 Error Message: "Quant cannot process the selected data file or the Quant result file has been deleted. Failed to load XML data at the root level is invalid line 1 position 1." 
 Context: This error appears during the setup process when modifying analysis methods, specifically when transitioning from MRM to dMRM. 
 
 If anyone has encountered similar issues or has insights into potential solutions, your advice would be greatly appreciated. Thank you in advance for your assistance.

howard_sanford · Answer

Hello Yasar , 
 To switch from an MRM method to dMRM in acquisition you must have acquired an MRM data file that can be successfully processed in Quant. If for whatever reason the data file cannot be processed in Quant, then you will receive the error you are seeing. 
 You can try to manually create a new quant method from acquired MRM data using your acquired data file and then you should be able to see what issue is preventing the method creation and reporting necessary to create the dMRM method. 
 The MRM database familiarization guide has an overview of how to go from an MRM method to a dMRM method, starting on page 22. 
 MRM_Familiarization.book (agilent.com) 
 There is also a video on the Community that has a good example of the process. 
 (+) MassHunter Acquisition - Converting an MRM Method to a Dynamic MRM Method - Videos - Mass Spectrometry Software Portal - Agilent Community