HEPES vs TRIS - Least Worst Option?

I typically try to clean up and buffer exchange samples into ammonium acetate or (worst case) PBS; however, I need to compare some results with either 50mM HEPES or 20mM Tris.

Wondering if anyone has suggestions as to which one is worse in terms of contamination and/or buildup? 

To give some extra detail:

  • This is on a 1290/6545XT LC/MS w/ AJS
  • Running intact protein MS with Water:ACN+FA
  • I use a PLRPS column and inject ~1 uL.
  • I divert the first 1 min to waste, in order to help "wash" the sample
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