What are causes of dropping of the mass reference ions?

Dropping of the mass reference 121m/z and 922 and no improvement even if i increased the isocratic pump flow rate from 2 mlmin to 4 ml/min. I added more Purine and HP0921 to the reference solution but no improvement. I checked the filter and it is OK. I checked if the there was air in the tube but all did not improve the abundance

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