Has anyone see a drop in sensitivity for d7-meprobamate and d7 carisoprodol over a 24-48 hr run?

We thought that the cleanliness had to do with the enzyme used but we are running a different enzyme on a recently cleaned instrument.  We have performed scans to make sure there isn't any contamination present.  Tunes look great. Start of run  24 hrs later  48 hrs later  Same samples re-injected but you can see the responses trending downward from the beginning of the run until they completely drop out.

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