What causes an unconfigured module multisampler error?

Mid-way through an injection during a sequence using an Agilent UHPLC that was being controlled by Waters Empower software the system had an unconfigured module autosampler error.  The sequence was aborted and the physical autosampler had a flashing red light.  The software lost track of the multisampler and the instrument and the L/ACE box needed a full restart before the sampler was recognized as a component of the instrument.  Does anyone know what may have caused this error to occur and what steps may be taken to prevent future reoccurances?

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