Hello,
I run a VOA system using an EST Analytical autosampler and concentrator as well as Agilent GC/MS (7890B and 5977A). This system is used for drinking water. Does anyone have any advice for improving internal standard responses? I have been running this system relatively nonstop for the past month and as expected, ISTD responses have dropped moderately from the last time the calibration curve was ran (~62% of the mid level calibration standard at the moment).
Some have said to bake out the GC for a certain amount of time to reduce the water in the system, but I have done this and seen very marginal increases (~3-5%). I have also heard that increasing the voltage to the MS would likely help that as well, but I don't want to risk throwing off my tune and lose more time trying to retune the instrument. I honestly just don't want to lose an excessive amount in recalibrating the instrument.
Let me know if you guys need any more information.
Thanks!
Nicholas Davis
