GC-microECD analysis question

Hi Madison,

that is unfortunately true. Compared to chlorobenzene as reference fluoro-compounds range from 0.01 to 10 times the response, thus not very big, whereas chloro-, bromo- or iodo-compounds go up to 10000 times the response. If you have very low concentrations (and nothing very big in the mix) a PD-HID might give you better results, but it's easily overloaded and you might need some switching techniques.

Regards,

Norbert

Thank you for your response. Is there any literature I can see on your reference of chlorobenzene? Asking as I would like to learn some more about it. (It is odd to me that Agilent's manuals do say that poly-fluorinated species see detects in the 10^7 Hz range - I have not seen that, and have asked Agilent application techs who have not seen it either)

Sadly, I believe you may be correct - we got this instrument as hand-me-down, and were hoping to use it as screening tool, while our high-use instruments run our grant work. Fluorinated compounds are currently our target of interest, but we may adapt down the line if there is a need.

When I need information about detectors I use the following books:

• Raymond P. W. Scott "Chromatographic Detectors - Design, Function, and Operation", Chromatographic Science Series Volume 73, Marcel Dekker, New York (1996). ISBN 0-8247-9779-5.
• Raymond Annino, Richard Villalobos "Process Gas Chromatography - Fundamentals and Applications", Instrument Society of America (1992), ISBN 1-55617-272-9.

For the ECD there was also a separate Volume from J. Chromatogr. A, full of useful articles, (gave it to someone and never got it back :-( )

Here are some pages from a presentation of mine.

I will add a Wiki article here in the Community in the Consumables area about the ECD, so please check every once in a while.

Norbert

When I need information about detectors I use the following books:

• Raymond P. W. Scott "Chromatographic Detectors - Design, Function, and Operation", Chromatographic Science Series Volume 73, Marcel Dekker, New York (1996). ISBN 0-8247-9779-5.
• Raymond Annino, Richard Villalobos "Process Gas Chromatography - Fundamentals and Applications", Instrument Society of America (1992), ISBN 1-55617-272-9.

For the ECD there was also a separate Volume from J. Chromatogr. A, full of useful articles, (gave it to someone and never got it back :-( )

Here are some pages from a presentation of mine.

I will add a Wiki article here in the Community in the Consumables area about the ECD, so please check every once in a while.

Norbert