I discovered that the dioxane area became larger as compared to the dioxane area in calibration table. How will this affect the result? And why is the dioxane area becoming inconsistent?
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I discovered that the dioxane area became larger as compared to the dioxane area in calibration table. How will this affect the result? And why is the dioxane area becoming inconsistent?
Hi Peggy,
If you still have your calibration solutions (ISTD+ESTD), inject the one which is closer to your sample's concentration and check if your ESTD's area became larger as well. If it is in the same proportion as for the ISTD, I don't think you should worry. It means the ISTD is actually doing its job.
I calculated using the area ratio of ISTD in 100ppm with the ISTD in sample. And the value is 0.9614.
The area ratio of ESTD in calibration solution with the sample, and the value is 0.9086.
Is this what you meant?
That's not much of a difference. If you run a standard is it within 85-115%?
If you inject again a solution of standard (ESTD) with your internal standard (ISTD) that you used to do your calibration, do you get the expected areas? Are they both larger? What about the ratios?
my concentration is less than 200ppm. Such difference will not be significant too?
my concentration is less than 200ppm. Such difference will not be significant too?