This Information Applies To: Agilent 1100, 1200, 1290, and 1260 Quaternary Pumps
The Multi-Channel gradient valve may create pressure fluctuations and retention time shifts due to cross port channel leaks. To check if there are cross port leaks in the MCGV, the "bubble test” is an easy and quick way to confirm it.
The cross port leak will result in solvents from unintended channels to mix with the mobile phase and will result in retention time shifts as well as pressure fluctuations.
Steps to Follow
If the cross port leak is determined, contact your local Agilent Support Representative for further support.
Learn how to effectively use your Agilent Multi-Channel Gradient Valve:
Good practices for use of the Multi-Channel Gradient Valve in Agilent quaternary pump modules on Agilent Community