Some COVID-19 vaccines are using lipid-based nanoparticles to act as drug delivery systems for effective on-target payload delivery. Just like any finished product components, lipid nanoparticle components—like pegylated lipids, cholesterol, ionizable cationic lipids, and cryoprotectants—must be verified for ID at receipt before use in vaccine manufacturing. In a recent application note, the Vaya handheld Raman spectrometer, based on spatially offset Raman spectroscopy (SORS), was shown to probe through opaque and transparent containers and ID the different components used in the making of lipid nanoparticles for easier, low cost ID at receipt—with no sampling, no container opening, and no sampling booth required.
Download the application note for full details: Identification of mRNA Lipid Nanoparticle Components with the Agilent Vaya Raman Spectrometer