Pharmaceutical raw materials and APIs are often stored and shipped in blue drums. Made of high-density polyethylene (HDPE), these drums are durable, reusable, and protect raw materials effectively from photodegradation. Handheld solutions based on conventional Raman spectroscopy cannot perform the ID test directly through these drums. Opening of the containers is required to enable analysis through the transparent plastic liner.
In a recent application note, the Vaya handheld Raman spectrometer—based on spatially offset Raman spectroscopy (SORS)—was shown to probe through blue drums and ID pharmaceutical raw materials, with no sampling, no container opening, and no sampling booth required. By combining SORS with onboard wizard-based method development, Vaya users can quickly verify the identity of APIs and raw materials through thick opaque containers.
Download the application note: Opaque Container Analysis Capabilities of the Agilent Vaya Handheld Raman Spectrometer
- Vaya Handheld Raman Spectrometer FAQs
- Application note: Rapid Identification of Raw Materials Inside Packaging
- White paper: Identifying Raw Materials Inside Containers Using a Handheld Raman Spectrometer - Reducing the cost of quality with SORS technology