Hi,
We have a PAL RTC autosampler equipped with static headspace syringe tool and connected to an Agilent 7250 GC-qToF-MS. When a headspace sample is injected we see a pressure drop in the inlet at all split levels below 40 and it goes into pneumatic shutdown. When split level is >40, the pressure instead increases and the same pneumatic shutdown occurs. Gas saver is turned off. Diagnostics indicate an inlet leak, but this goes away after some time and doesn't occur when injecting liquid samples. What am I doing wrong here? I have tried changing the liner/septum and get the same result. I feel this may be due to low flow rates and the headspace syringe directly injecting a large volume (1mL) into the inlet, but that doesn't explain the pressure rise above certain split ratio. Ideally we would like to do splitless injections to recover as many analytes as possible.
Thanks
