Good afternoon everyone,
We are performing the media replacement accuracy test in our 850-DS Dissolution Sampler Station and our test is failing (specification <=9mL), as per table below:
Friday Run:
| # | Initial Weight | Final Weight | Difference | Actual Difference |
| 1 | 1318.53 | 1309.16 | 9.37 | 9.44 |
| 2 | 1304.27 | 1295.04 | 9.23 | 9.30 |
| 3 | 1322.53 | 1313.72 | 8.81 | 8.87 |
| 4 | 1314.02 | 1305.46 | 8.56 | 8.62 |
| 5 | 1321.64 | 1312.12 | 9.52 | 9.59 |
| 6 | 1327.79 | 1316.99 | 10.80 | 10.88 |
| 7 | 1331.36 | 1322.33 | 9.03 | 9.09 |
| 8 | 1315.28 | 1304.31 | 10.97 | 11.05 |
Today, I just tested 2 vessels and the results were fine. When I tried to run all the vessels again, the difference is even higher now (around 14mL) for all vessels.
Before performing the media replacement test, we cleaned the system by rinse cannula, rinse pump in and out, pump media replacement in and out and performed prime under calibration.
The configuration set is the one used in the IOQ and that we always perform this test every 6 weeks.
Could you help me to figure out what can be the problem, considering the volume accuracy test is passing, please?
Thank you so much.
Have a nice day.
Best regards,
Suzany
