Is it possible that high Mw polymer damages C8 column?

Hi, the column we use is C8 3um 50*4.6mm. Recently, we included one excipient (high Mw polymer-800K) into the product. We need to run assay method to determine drug strength (small molecule). If polymer can be dissolved in the diluent but can not be separated from sample, I am wondering if the high Mw polymer will clog the column and damage the column. Is there any way to protect the column? Thank you.

Parents Reply Children
No Data
Was this helpful?