Is it possible that high Mw polymer damages C8 column?

Hi, the column we use is C8 3um 50*4.6mm. Recently, we included one excipient (high Mw polymer-800K) into the product. We need to run assay method to determine drug strength (small molecule). If polymer can be dissolved in the diluent but can not be separated from sample, I am wondering if the high Mw polymer will clog the column and damage the column. Is there any way to protect the column? Thank you.

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