Binary code error and won't open MassHunter Quant Analysis

Dear colleagues, I keep experiencing the same issue with not being able to open some batches in MH quant (5.1, G7201D / Version D.01.01 / Build 653.5), while others work just fine. I have integrated three batches that were all analyzed, and chromatograms recorded on the same day. Out of the three, I can only open two of them on the next day. For the one not working, I get "Failed to open batch file. Failed to read batch file from binary." No software update or version change happened, I used the same computer, and no file protections or restricted access is attached to the three batch bins.

This keeps happening every few batches. I can create a new batch and access the data that way, but all integrations are gone of course. Can anyone please tell me how to avoid this happening?

Thanks,
Ronald   

Dear colleagues, I keep experiencing the same issue with not being able to open some batches in MH quant (5.1, G7201D / Version D.01.01 / Build 653.5), while others work just fine. I have integrated three batches that were all analyzed, and chromatograms recorded on the same day. Out of the three, I can only open two of them on the next day. For the one not working, I get "Failed to open batch file. Failed to read batch file from binary." No software update or version change happened, I used the same computer, and no file protections or restricted access is attached to the three batch bins.

This keeps happening every few batches. I can create a new batch and access the data that way, but all integrations are gone of course. Can anyone please tell me how to avoid this happening?

Thanks,
Ronald   

Hello Columbia_METALab ,

I don't believe this was a known issue with Quant B.05, though it is out of support at this point. I can suggest a few things to try.

First would be general PC maintenance. Clean up Windows temp files and defragment the hard drive.

Next you can try to reset quant's user preferences. In current versions there is a tool for this called Restore User Settings. You can check in the Windows Start menu under Agilent MassHunter Quantitative->Quantitative Analysis Tools->Restore User Settings

Before doing this make certain you have any custom column or screen layouts saved in Quant. Also make note of what report method you are using, as this information will also be cleared when you use the tool. Then close all open copies of Quant and run the tool. 

If that tool is not available, you can manually clear the preferences by going to the currently logged in user’s appdata folders. The easiest way to locate these is to enter %appdata% into the location line in the file browser. This should go to C:\User\logged in username\AppData\Roaming. From there go to the Agilent_Technologies,_Inc folder and delete the MassHunter Quant folder. 

Another possibility may be a corrupted quant method. You could try making a new method from acquired data, or loading a method from a batch that was created before you began having these issues.