We have qTOF 6546. Is there abybody who tried to analised nitrosoamines on qTOF. According to the Agilent application "Determination of Nitrosoamines Using the High Resolution Agilent 6546 LC/Q_TOF" (link below) it is possible to reach the sensitivity up to
0,1 ppb. I have tried to do this but for e.g NDMA the sensitivity about 100 ppb is maximum i could reach.For other nitrosamines it is hard to get 10 ppb.
I did some online reaserch and found the article: "Nitrosamine Impurities Testing by LC-MS Methods from the United States Pharmacopeia General Chapter <1469>" (link below) where I found that information:
"Our laboratory experienced sensitivity issues with an ultra-modern HRMS detector (Agilent 6546 Q-TOF), and to verify the results different HPLC columns, solvents, and reagents were tested. Chromatographic system suitability criteria could be met, but it was not possible to meet system suitability for overall identification and sensitivity.
Do you have any experience with nitrosoamines on qTOF and you could give me some hints about e.g MS tuning? Do tou know how can I contatct with the authors of that aplication to ask for more information?
Thank you for nay help,