I have PEG contamination in my LC. I tried flushing with hot water and that did not work. I also tried a mixture of 10% conc. ammonium hydroxide, 80% IPA, and 10% Water. This also did not work. Any other suggestions for other flushes?

Question

I see Na adducts of PEG on all 4 channels. I have been rinsing for days and have not seen the intensity decrease much.

Dr. Know · Accepted Answer

Hi molsenbison, 
 please see the thread on ResearchGate: (7) What is the best way to remove/clean polymer (PEG) contamination in LC-MS system? | ResearchGate 
 Regards, 
 Norbert

I have PEG contamination in my LC. I tried flushing with hot water and that did not work. I also tried a mixture of 10% conc. ammonium hydroxide, 80% IPA, and 10% Water. This also did not work. Any other suggestions for other flushes?

Top Replies