We have utlilized Agilent/HP MSD's for over 35 years at Eastman Chemical Company. They are very reliable and cost effective tools for compound identification in complex mixtures. We have >40 GC-MSD's located worldwide to characterize unknowns. NIST user librarys are automatically updated and shared over the corporate network nightly (>50,000 EI and >5,000 tandem spectra).
Over the years I have thoroughly documented and shared information presented in publications, ASMS presentations, workshops, and seminars:
I believe other mass spectrometry users will find the information on ei, derivatization (TMS and methyl), library searching, spectral deconvolution, and unknown analysis beneficial in their R&D efforts.
Also, information is presented on the general identification of "known unknowns" in commercial products using accurate mass lcms methods. A very targeted discussion is also discussed for the systematic identification of surfactants.