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What are the pros/cons of adjusting split ratio rather than adjusting sample concentration?

Question asked by gregory.mountain on Jun 24, 2020
Latest reply on Aug 19, 2020 by Tim Strutt

In what scenarios would you adjust split ratio to alter signal level rather than diluting the sample? Obviously it is harder to boost signal by concentrating sample, this question is geared more towards reducing signal when sample signal is too high.