AnsweredAssumed Answered

Molecule (melatonin) won't ionize with ESI, has anybody else run into this problem?

Question asked by kebattaglia on Mar 10, 2020
Latest reply on Apr 16, 2020 by dannymobbs

I'm trying to identify melatonin and seratonin.  When I run the standards, each one has it's respective peak but it's the molecular parent ion, not a fragmentation that shows up.  I'm currently using ESI as the ion source, but it seems like APCI may be a better fit given the problems I've run into. Before purchasing the APCI ion source, I want to know if there are other ways to trouble shoot this issue, with changing parameters, etc.  Thank you!