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Mass Spectral Gaussian Smoothing

Question asked by chrisjg on Oct 16, 2019
Latest reply on Oct 23, 2019 by ryoboyle



Can anyone provide an background information on how the Gaussian smoothing in the Spectral Options -> Mass Spectra window works?


More specifically how would you go about selecting a justifiable width value?


I have a lot of noise in my mass spectrum which is obviously affecting the quality of the data and smoothing will be appropriate.  I work in a regulated environment though so anything which affects the appearance of the raw data (like smoothing) needs to be well justified. 


I'm using Openlab Chemstation Edition C.01.07 SR1 to control a single quad 61xx MSD.  My analytes are quadruply charged and weigh several thousand Da.