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Dear Agilent team, I was wondering if you maybe have some information on using  Enhanced Matrix Removal - Lipid kit (EMR-Lipid) for lipid separation in brain homogenate? As brain homogenate has a lot of lipids and proteins, the Signal-to-Noise ratio when

Question asked by olin on Sep 12, 2019
Latest reply on Sep 13, 2019 by don_gage

Dear Agilent team,

do you maybe have some information on using  Enhanced Matrix Removal - Lipid kit (EMR-Lipid) for lipid separation in brain homogenate (eg. prepared in ratio 1:9 in PBS).  As brain homogenate has a lot of lipids and proteins, the Signal-to-Noise ratio of quantification of specific analytes using LC-MS is too low. Do you maybe think that your  Enhanced Matrix Removal - Lipid kit (EMR-Lipid) could improve the sample preparation, thus lowering the matrix effect of brain homogenate? Thank you in advance. 
Best regards. 

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