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Microsomal stability on a single-quad LC-MS?

Question asked by swilson88 on Apr 12, 2019
Latest reply on Sep 17, 2019 by swilson88

Is anyone performing microsomal stability on a single-quad LC-MS? I've seen papers where researchers have used both simple UV and LC-MS detection, but most contract testing labs seem to use triple-quads, LC-MS-MS. Is a MS-MS really necessary when you're just monitoring the disappearance of the parent compound? I'd like to bring microsomal stability/clearance and Caco-2 testing in-house. It would be really nice if I could use one of our existing LC-MS systems.