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use low concentration HCL on LC-MS

Question asked by xiaopang2 on Feb 12, 2019
Latest reply on Feb 25, 2019 by dannymobbs

Can 0.012 N HCL be used in LC-MS? I know HCL shouldn't be used for LC column. This is a old method which is used to analyze Malic acid in our lab. The are two peaks in my pure standard chromatogram. The method is using UV detector at 210 nm, mobile phase is 0.012 N HCL and water as solvent. I wanted to use the method on LC-MS to identify the 2nd peak. Is it safe to use 0.012 N HCL on LC-MS? Will it damage the analyzer? I use a mixture of low concentration of Nitric acid and HCL on ICP-MS to analyze heavy metal in our products regularly. But I don't know that I can 0.012 N HCL on single-quad(Agilent 6100) or not. Thanks in advance