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Peak tailing in SFC-MS (while good peak shape in SFC-UV)

Question asked by xiaoz on May 5, 2018
Latest reply on May 8, 2018 by dannymobbs

I was running a SFC method for separation of chiral isomers. The method works very well and we got very good peak shape when using UV as the detector. But when we use the exactly the same method and switched to MS as the analyzer, we have very significant peak tailing. Is there any suggestions how we can improve the peak shape in SFC-MS? Really appreciated!