I did a quick literature search and quickly found a number of applications where difluphenican was used in a reverse phase method with water and an organic as the two mobile phases. I am assuming you mean glyphosate and not “glyphosate”.
It is extremely polar, with a logP of -4.6. Difluphenican has a logP of 4. While that is a bit non-polar in nature, it is by no means insoluble in water. Glyphosate is the more challenging compound in that it needs to be derivatized in order to get retention in a typical reverse phase method.
Please submit a ticket with your local columns and supplies group and they will be able to further assist.