To cut to the chase: No, peak areas calculated in MassHunter will not be equal to the peak areas calculated in GC/OpenLAB ChemStation software.
GC ChemStation and OpenLAB ChemStation use response units of pA for FID data whereas the response axis for GC-FID data collected in MassHunter or MSD ChemStation is unit-less. Since the software products are not using the same response units then the peak area calculated by these products will be significantly different, even if they are integrating the same chromatographic data.
Thanks for the information. So its it fair to say that the pA units displayed on the y-axis of the I/OQ report plots are “derived”?
I cannot say for certain about the pA units on the I/OQ report. Agilent OQ reports are generated in the Agilent Compliance Engine and I am not familiar with that software.
Generally speaking, when comparing data acquired/analyzed in multiple different software products you want to compare the calculated amount/concentration results as opposed to the peak integration results. As long as the quantification method is properly calibrated and the peak integration is reproducible then similar results should be calculated by the different software products.
I went ahead and marked a correct answer on this post as there was no follow-up on my last reply. Please let us know if you require any further assistance.
Next time someone brings this up… (buys a 7890, installs ICF for Empower and wants higher area counts from their FID),
Please let them know that:
“To get more area counts, open up your method set, open up a derived channel and put a multiplier on the left side of the first tab, choose your detector channel on the right side, save method set. Done.” Tip provided by our former Empower admin.
This field will accept values between -1^5 and 1^5 (±10,000 not inclusive).