2 Replies Latest reply on Nov 23, 2017 1:27 AM by gchaplain

    Calibration curves ICPMS




      I am currently carrying out validations for USP 233 for ICPMS.


      Regarding calibration curves I am using a 5 point calibration curve starting from Blank (Matrix). Should the calibration curve on MassHunter be set to Offset or Ignore?


      Many thanks,



        • Re: Calibration curves ICPMS

          Hi Tim,

          I updated the tags on this for better visibility .


          • Re: Calibration curves ICPMS

            Hi Tim,


            As a rule of thumb I would always ignore the intercept.


            Reason being is that you will be including a result that you have not measured.


            You are using a blank for your lower end concentration, meaning that the blank result (if there is one) will be included in the calibration.


            NOTE: This is a statistically debated area. Personally, though the calibration curve you produce may not be straight line linear at the lower end concentrations (due to noise interfearance).


            Hope this helps.