The *.D directory as that is the repository of everything related to the sample. There are files underneath that may be necessary in most laboratory environments for good laboratory practices and for troubleshooting problems. Deleting files underneath a data file subdirectory is not recommended for normal daily use as hard drive space is cheap now.
I started with a GC/MS single quad data file that is 15.1MB. This particular operator uses an acquisition method and a data analysis method instead of one combined unified method, so there are two copies of a *.M in the *.D directory and a copy of the data analysis method under the AcqData subdirectory as well. I deleted those three method subdirectories. No problems. Then I thought I would throw caution to the wind and deleted every file that was not data.ms, *.xml, *.bin, or *.xsd.
The data file subdirectory is now 3.3MB and loads in MH Qual just fine. I tried zipping the entirety of the *.D subdirectory and everything underneath it and it is 981kB.
I hope that helps.
Thanks for looking into this for me Paul.
I will look into that more and try out your suggestions. My issue was that I am sharing data on Sharefile for my students to download and then analyze. Sharefile hated the number of files inside each .d directory and would slow to a crawl. Large file sizes were not an issue; it was the large number of files that was the issue. Our ITS folks confirmed this. I have been using zip files as a solution but on a few occasions that wasn't an option hence my question.
Will post again once I am tried this out with my findings/comments
You can delete all the files underneath the *.D subdirectory. You need the *.D top directory with the AcqData subdirectory and the *.xml, *.bin, *.xsd, etc in there. You can delete any methods, tune files, and tune reports, but the rest need to stay. Dropbox and OneDrive do not have a limitation like that.
I just wanted to follow-up to see if this issue is resolved. If so, please come back to the post and click the "Correct Answer" button on the response that helped so it will make the solution more visible. If you still need help, just let us know and we would be happy to continue working with you.
I also updated the tags on this thread to make it easier to search.