I have a 6520 LC/MS QTOF with Masshunter B.06.00. It has a dual ESI source, and we'd like to use the second needle to introduce sodium hydroxide to enhance deprotonated ion formation. Currently we are injecting the NaOH with a T into the line for inline chemistry. We are curious about the feasibility of trying gas phase chemistry instead because then we wouldn't make our primary ESI needle dirty with NaOH.
Thanks. - Kelsey