What is the future for Openlab Chemstation?

We have a new 8860 GC with Openlab CDS (VL) vs 2.3 software. This software does not have the functionality of Chemstation A.10.02 that we use on our 6890 GC. What is the future for Openlab Chemstation, someone showed it to me and it looked like it works similar to the old Chemstation with the same functionality. I was however advised that Openlab Chemstation is not available to new users anymore and that it is being phased out, what would your comments be on this? The Openlab CDS is a lot more difficult to work with, takes longer for results to be generated and the calibration functions I need is not available.

We have about 40 components in one calibration but the compounds are in 3 separate mixtures. With Openlab you cannot have different mixture for one calibration, for Chemstation you can. With Openlab we have to use 3 processing methods for each run, then type in all results in the order they should be in.  For me it is a huge step backwards to go from Chemstation to OpenLab CDS. I need some independent advice please.

  • Thank you this helps a lot, Agilent product developers said there was no way of doing my calibration. I shall try this calibration when we are out of lock down.

  • Hello,


    I added some tags to this post to increase visibility.


    As far as I know, OpenLab ChemStation is still being sold and there are no restrictions on its sale. Sales for different regions are handled differently though, so ultimately you should contact your local Agilent sales team for up-to-date information on OpenLab ChemStation availability in your country: Contact Us | Agilent 


    It is possible to setup a calibration in OpenLab CDS when all compounds cannot be prepared in the same calibration standards. You just need to make sure to assign unique calibration levels to each group of standards. For example, let's say you have 40 compounds and need to use three different sets of calibration standards where standard 1 includes compounds 1-15, standard 2 includes compounds 16-30, and standard 3 included compounds 31-40 and want to setup a 3 level calibration for each compound. You can do this by assigning compounds 1-15 calibration levels 1-3 in your processing method, compounds 16-30 calibration levels 4-6, and compounds 31-40 calibration levels 7-9. This way each calibration standard has unique calibration levels so that they do not impact the calibrations of compounds from other standard mixtures. 


    Hopefully this helps. 

  • Good morning,


    What is the difference between OpenLab Chemstation and Chemstation? Do you still get Chemstation and what is its future? I managed to persuade our Agilent agent to at least give me a quote for OpenLab Chemstation. As it is quite expensive I want to be sure it would work for me. If I use Chemstation I know it would work, because it is what I am using.

    I tried the calibration method you suggested but it did not work. I was only allowed in the Lab for a short period and want to try it again when I have more time in the Lab. The compounds were in 2 mixtures and were run in two sequences, I maned the first compounds level 1 to 6 and the second ones level 7 to 12. It does the one set of levels correctly and does not calibrate the other set correctly.




  • I believe the issue is that you made 2 sequences. What ryoboyle meant (I believe) is to create 1 sequence and assign the different calibration level that way. 


    As far as the difference, Openlab CDS Chemstation is the latest Chemstation product. It is part of the big banner Openlab CDS which includes Openlab CDS Chemstation, Openlab CDS 2 and Openlab CDS EZ Chrom. That version of chemstation is still being sold. Normally when we refer to Chemstation alone, we mean version A and B of chemstation which are somewhat still supported by best effort in some area, while other is just not supported. It is a much older version of Chemstation which I believe is not sold anymore.


    hope this helps

  • Hello,


    The issue is because the processing methods are stored with the data set you ended up with 3 copies of the method one in each data set and the master method. You need the master method to reflect both data set methods. The easiest way is to run all your standards in one sequence and then when done update the master method. Since you did not do that in this case then you could create a combined result set from the 2 sequences by using the create new result set option in DA processing and then use a similar workflow. The last option would be to work through the master method by processing one data set and updating the master method. You would then need to link that master method into the second result set and process the second set of standards making sure not to clear any of the previously calibrated levels(i.e. do not use clear all calibration levels). Once the full curve was built you could update the fully calibrated method to the master method to use in new sequences or existing data sets.


    Marty Adams

  • Hello,


    Thank you, this is very helpful.




  • Regarding the calibration using different mixtures and such.


    The answers so far mention how to use calibration levels to achieve what you want. Another option, we currently use, is modifying the compound amounts directly in the sequence. This can be done as the sequence is created in the Acquisition software, or in the Data Analysis application in the "Injection list".


    In the Acquisition application, simply select your "Cal. Std." row, and then below change the tab to "Compound Amounts". You need to select a Process method, otherwise the software have no clue what compounds are in the method.


    In the Data Analysis application, click in the column "Compound Amount" for a calibration standard row. This opens a secondary window inside the "Injection List" window.


    The benefits of this approach is the compound amounts are handled per sample, which I find more straight forward than the compound amounts per level assigned to samples. It also allows you to modify the compound amounts without having to modify the processing method, which can be beneficial if you're often correcting amounts prior to calibration. The two options are not exclusive and can be mixed, with the "Amount in sample" overruling the "Amount in method". The downside is when you have multiple calibration standards at each level, then you need to ensure each is correctly filled out, rather than just the level assignment being correct.


    The "Import Sequence from CSV or TSV" unfortunately does not support this feature, however, copying rows are handled correctly. More advanced, this feature is nicely implemented in the OpenLab SDK. This allows us to fully build our sequences with LIMS values directly, even calibration standards, which was a thing we never got around to using ChemStation.

  • Thank you, I shall try this.



  • We invested in OpenLab Chemstation after struggling for a year, it is a lot more expensive than OpenLab CDS but worth is. Please do not discontinue the Chemstation, for me there is no comparison.Nerd

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