FTIR Cary 630 - Simethicone Identification

Hello everybody,

I have a problem in the identification of simethicone capsules. I am currently following the USP method, which indicates that I should use the standard solution, blank and sample solution according to the assay, therefore, the samples are diluted in toluene, circa 2,5 mg/mL.

I have created a new library and added the spectra of standard and blank. The problem is when I compare the spectra from the library with the spectra from a recently prepared standard I get good similarity results in both the comparision standard-standard and standard-blank. This way I can´t properly identify simethicone in a quantitative way, because there is no significant difference between the responses. Also, the scalling is not helping me to do a qualitative comparision, because It is auto-scaled (0 to 1). Is there any way to fix the false positive result and to adjust the graffic scaling?

First one is standard, second one is blank.

Parents Reply Children
No Data
Was this helpful?