UV-Vis ChemStation-ChemMain.exe has encountered a problem and needs to close

Both online and offline software for Agilent 8453 UV-vis spectrometer could not open...Error message (see attached) appears when opening the program. Clicking "Don't send" leads to software close. Any solutions? Thanks!

Parents Reply
  • If you got his far, you should have entered your registration numbers.  This is most likely communicating by LAN, but GPIB was still supported.   The revision B.04.02 and Windows 7 32 bit are out of support, but we certainly want to make every best effort attempt to help.  Although the software has been updated since it was released (circa 1994), there may unspecific causes for a ChemMain error. 

    All of the advice so far has been spot on, so let's review a bit.

    I am assuming that this is not  21 CFR Part 11 compliance Security Pack G1813AA software.   If it is, contact your local Agilent Service for a quote to re-install.

    1. Back up your data & methods, etc..  (i.e. Make a copy of the 1 folder located at C:\Chem32)
    2. Uninstall the software from Add/Remove Programs.
    3. Restart the computer
    4. Delete the chemstation.ini file located at C:\Windows
    5. Delete the Chem32 folder.
    6. Restart the computer
    7. Install the software.
    8. When you get to the field in your print out, add your instrument.
    9. The installation should complete.


    If this does not work, re-image the hard drive, then install.


    Good luck.


    Best regards,



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