I have a similar question. I am using MassHunter version B.07.01, Build 7.1.7112, for 6400 Series Triple Quadrupole. I am getting warning messages that the Programs (C:) drive is getting full. Restarting the computer and deleting the MassHunter processes gets me more space. I don't know when the drive was last defragmented. (Last June I was suddenly dumped back into LC/MS land after being out for 3 years.)
If the C-drive is too full for a successful disk defragmentation, what are my options?
What is MassHunter putting on the C-drive? I had assumed everything was going to the Data drive when the software is running. I know the data is going there. My computer skills are 20+ years old.