I am running on an Infinity 1260 II Ultivo LC/QQQ and have a problem when running check tunes. Every time I run a check tune, I get an out of tolerance result where the only parameter out of range is the gain factor. It fluctuates between being out of range on the low end (0.6 or 0.7) and the high range (1.3 to 1.5), it is not consistently too low or too high. I am having to constantly autotune the QQQ which takes longer to do. The autotune will pass with a gain factor of 1.0, and then check tune the next day will fail due to gain factor.
Has anyone seen an issue with gain factor values? Is there any specific part of the mass spec that the gain factor is associated with that may need attention (maintenace, cleaning, replacement etc.)? Any input would be appreciated.