Optimizing Pump Compressibility Compensation Setting

The compressibility compensation default setting is 100 × 10-6 /bar for the

pump. This setting represents an average value. Under normal conditions the

default setting reduces the pressure pulsation to values (below 1% of system

pressure) that will be sufficient for most applications and for all gradient

analyses. For applications using sensitive detectors, the compressibility

settings can be optimized by using the values for the various solvents

described in Table 9 on page 61. If the solvent in use is not listed in the

compressibility tables, when using isocratic mixtures of solvents and if the

default settings are not sufficient for your application the following procedure

can be used to optimize the compressibility settings.

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