When the Gameboy GA208A Insta Pilot is connected, Empower 3 SP4 communicates with the 1260 HPLC. As soon as the Gameboy GA208A Insta Pilot is disconnected, the Empower 3 SP4 communication to Sample, Quat. Pump and Column Comp disconnect in Empower, but the Detectors stay connected.
Appears there is a Device Dependency almost like GA208A Insta Pilot is acting as a bridge or intermediary for communication. That is why its disconnection could be disrupting the communication pathway.