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High System Pressure Despite Open Purge Valve (Agilent 1100, G1312A)

Falko.Emil

Hello everyone,

I am a student at a technical university currently in my practical phase, working with an Agilent 1100 HPLC system. I’m facing an issue where the system pressure remains unusually high, even when the purge valve is open (over 60 bar at a flow rate of 1 mL/min using ultrapure water). Even after 30 minutes, the pressure does not stabilize and continues to creep upwards.

To troubleshoot, I’ve already replaced the PTFE frit in the purge valve, but the high pressure persists. I then completely removed the purge valve and checked the pressure again – the high pressure remains. I can rule out the degasser as a potential issue, as it was recently replaced. Therefore, I suspect the problem or blockage is somewhere in the pump system itself.

I’m working with a binary pump model G1312A. Unfortunately, I’m not an expert and feel quite isolated in handling this issue. I haven’t been able to find a clear guide on what steps to take next.

Does anyone have suggestions on what I can do next? I would greatly appreciate any helpful advice.

Thanks in advance!

Best regards,

Falko

  • +1

    Try removing the capillary the comes out of the damper, that is what is reading the pressure- see part # 9 on page 78 of the user manual: G1312-90006_Agilent1200SeriesBinaryPump.fm

  • +1 in reply to jhagel

    Thank you for the suggestion! I removed the capillary coming out of the damper, and this resolved the high-pressure issue. Without it, no pressure builds up.

    During the process, I noticed that where the manual indicates the mixer should be, specifically between the damper and the purge valve, there’s a small steel cartridge installed. It’s clear that deposits have built up there, likely causing the high pressure. Unfortunately, we don’t have a replacement cartridge on hand. However, we do have an unused "Mixer" (G1312-87330) available.

    My question now is whether this mixer is meant to be installed as an empty chamber or if a cartridge is also required inside it? I haven’t been able to find any information on how it should be used.

    If anyone has experience with this part of the system or knows whether a cartridge is necessary, I’d greatly appreciate any advice!

    Best regards,
    Falko

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