Hello everyone,
I am a student at a technical university currently in my practical phase, working with an Agilent 1100 HPLC system. I’m facing an issue where the system pressure remains unusually high, even when the purge valve is open (over 60 bar at a flow rate of 1 mL/min using ultrapure water). Even after 30 minutes, the pressure does not stabilize and continues to creep upwards.
To troubleshoot, I’ve already replaced the PTFE frit in the purge valve, but the high pressure persists. I then completely removed the purge valve and checked the pressure again – the high pressure remains. I can rule out the degasser as a potential issue, as it was recently replaced. Therefore, I suspect the problem or blockage is somewhere in the pump system itself.
I’m working with a binary pump model G1312A. Unfortunately, I’m not an expert and feel quite isolated in handling this issue. I haven’t been able to find a clear guide on what steps to take next.
Does anyone have suggestions on what I can do next? I would greatly appreciate any helpful advice.
Thanks in advance!
Best regards,
Falko