PAHs (Polycyclic aromatic compounds)

Hello, I am working on GC/MS (8890 GC-5977B MSD). I run some PAHs (Polycyclic aromatic compounds) using HP-5MS column but the responses of some compounds that have long retention time (high boiling point and high polarity) are very low. I tried raising the MS source and quad temperature but it does not seem significant. Any advice for improve the response?  Thank you for your help.

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  • Its not recommended to change source and and quadrupole temperature. What is mass range of compounds you are trying to analyze? What is your GC injection temperature and oven program?

  • Changing the ion source temperature is no problem at all. In fact, most operators should increase it higher than the default 230° C temperature.  I recommend 275°C for most all applications.  That temperature does change the spectral tilt, reducing the 502 abundance somewhat, but increases the amount of time between source cleanings by having more of the source area hotter.

    Changing the quadrupole temperature is not a good thing, though. The lifetime is reduced a bit if you run the quad at 200°C all the time.  The default 150°C is fine for all but a very, very few ultra high temperature applications.

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  • Changing the ion source temperature is no problem at all. In fact, most operators should increase it higher than the default 230° C temperature.  I recommend 275°C for most all applications.  That temperature does change the spectral tilt, reducing the 502 abundance somewhat, but increases the amount of time between source cleanings by having more of the source area hotter.

    Changing the quadrupole temperature is not a good thing, though. The lifetime is reduced a bit if you run the quad at 200°C all the time.  The default 150°C is fine for all but a very, very few ultra high temperature applications.

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